hypothyroidism in β-thalassemia intermedia patients with and without hydroxyurea

نویسندگان

omid reza zekavat hematology research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran

ali reza makarem student research committee, jahrom university of medical sciences, jahrom, iran

sezaneh haghpanah hematology research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran

zohreh karamizadeh department of pediatric endocrinology, nemazee hospital, shiraz university of medical sciences, shiraz, iran

چکیده

hydroxyurea (hu) has been successfully used in patients with β-thalassemia intermedia (β-ti). we aimed to evaluate the effect of the long-term use of hu on thyroid function in patients with β-ti. seventy-five patients with β-ti aged≥11 years and taking hu were randomly selected during 2010 in southern iran. thirty-one patients with β-ti without hu were considered as a control group. serum levels of thyroid stimulating hormone (tsh) and t4 were measured. the mean age of the participants was 22.7±5.1 years (age range=12-41 years). serum ferritin level had no significant correlation with hu consumption (p>0.05). overall, we detected 10 (9.4%) patients with hypothyroidism. we found that the use of hu at a dose of 8-15 mg/kg/day has no significant association with thyroid function in β-ti patients. however, due to the small sample size in our study, documentation of this finding needs further studies with higher numbers of patients.

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Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea

Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...

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Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea

Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...

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عنوان ژورنال:
iranian journal of medical sciences

جلد ۳۹، شماره ۱، صفحات ۶۰-۰

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